ICAM1 and neoplasm: The inhibitory action on tumor angiogenesis has also been observed in studies with CBD, which appears to downregulate the Id-1 (inhibitor of differentiation) protein associated with the aggressiveness of breast cancer and to induce ICAM-1 (intercellular adhesion molecule 1) that are connected to the activity of TIMP-1 (tissue inhibitor of matrix metalloproteinases-1), responsible for the reduction of cell invasiveness in lung cancer [25,32,43].