In the process of tumor progression, ligands of endocannabinoid receptors, such as AEA, THC, cannabidiol (CBD, another pCB), or synthetic cannabinoid derivatives like WIN 55,212-2 (a non-specific agonist of CB1R and CB2R) and JWH-133 (a selective agonist of CB2R), act at different levels and through multiple signal transduction mechanisms. Here, CNR1 is linked to neoplasm.