Interestingly, GNAS mutations were detected in 11 of the 12 patients with MD-IPMN but in none of the patients with CP (p < 0.01), whereas KRAS mutations were detected in both diseases, but more frequently in MD-IPMN than in CP (MD-IPMN: n = 9/12 and KRAS: n = 2/10; p = 0.03). The gene discussed is GNAS; the disease is Menkes disease.