RCTs, such as FAIR-HF [32], FERRIC-HF [43], CONFIRM-HF [31], and EFFECT-HF [29], offer a multitude of evidence to substantiate the positive influence of IV FCM supplementation on HFrEF patients’ hospitalization rate, exercise capacity, quality of life, and prognostic biomarkers, such as NT-proBNP [28,44]. Here, NPPB is linked to hydrops fetalis.