The 2023 Procedure Guideline for Prostate Cancer Imaging with PSMA-ligand PET/CT by Afshar-Oromieh et al. [10] recommends bladder emptying immediately before image acquisition and suggests that hydration or diuretic use might help for PSMA tracers with renal clearance, while the European Association of Nuclear Medicine (EANM)/Society of Nuclear Medicine and Molecular Imaging (SNMMI) guideline [12] similarly highlights the benefit of furosemide with renally cleared PSMA tracers to decrease the number of false-negative findings for lesions adjacent to the bladder. This evidence concerns the gene FOLH1 and Familial prostate cancer.