Moreover, lifestyle factors, including smoking, cardiometabolic syndrome (including related comorbidities, e.g., diabetes, PCOS) [111], and a high-fat diet, not only predispose to cardiac disease, but also have a 16% increased risk of CHIP, particularly with ASXL1 mutations, and this risk persists even after quitting [112,113]. Here, STUB1 is linked to diabetes mellitus.