Another population-based study on TET2 mutations, using evidence from both in vivo studies of a patient cohort (358,000 participants in total) and murine models, showed that CHIP (VAF ≥ 2%) predisposed to AF development with an 11% increased risk, with TET2 mutations conferring the highest risk [83]. The gene discussed is TET2; the disease is atrial fibrillation.