SF3B1 and hematologic disorder: TP53, PPM1D, and spliceosome gene mutations (SF3B1 and SRSF2) are less common CHIP driver mutations, which lead to genomic instability (TP53), regulate hematopoietic stem cell renewal (TP53 and PPM1D), are essential for RNA splicing and gene regulation (SF3B1 and SRSF2), or are associated with high mortality rates and poor chemosensitivity (PPM1D), all being strongly associated with hematologic malignancies [40].