The adoption of optimized cut-offs with serial testing algorithms may be helpful in CKD patients, as shown in one study [11] that adjusted diagnostic cut-offs for CKD patients to match the specificity of hs-cTnT in non-CKD patients (from 14 to 50 ng/L), and together with an algorithm with serial testing, achieved a diagnostic performance of up to 55%. The gene discussed is TNNT2; the disease is chronic kidney disease.