ITCH and triple-negative breast carcinoma: The existing research has indicated that circITCH functions as a Wnt pathway negative regulator, leading to a reduction in tumorigenic potential in various cancers [183, 184, 186] Circ-ITCH was found to be reduced in triple-negative breast cancer by Wang et al. Subsequent research showed that cicrc-ITCH could attenuate the Wnt/β-catenin signaling pathway by functioning as a molecular sponge for miR-214 and miR-17.