Notably, EGFR amplifications in LUAD were observed to be enriched in minor subclones that did not expand in the primary tumour (Fisher’s exact test, P = 0.043; Extended Data Fig. 6a), suggesting either that these frequently occur late in tumour development or that subclonal EGFR amplifications do not always confer a sufficient selective advantage to engender a large clonal expansion. The gene discussed is EGFR; the disease is neoplasm.