In lung adenocarcinoma, UPP1 knockdown via shRNA reduced the protein levels of ENO1 and LDHA in H292 and H1975 cells, whereas overexpression of UPP1 restored the suppression of lactate production, glucose uptake and ENO1/LDHA protein levels induced by 2-deoxy-d-glucose in H1299 cells145. This evidence concerns the gene LDHA and lung adenocarcinoma.