Notably, compared with normal prostate epithelial cells, prostate cancer cells (PC3, LNCaP and DU145 cells) overexpress mRNAs encoding proteins that bind and activate OAS, such as Raf kinase inhibitor protein (RKIP), poly(rC)-binding protein 2 (PCBP2) and human endogenous retrovirus (hERV) envelope RNAs123,124. The gene discussed is PCBP2; the disease is Familial prostate cancer.