Another probiotic mixture containing L. lactis, L. cremoris, L. diacetylactis, L. acidophilus, and lactic yeasts also confers protection against LPS-induced depression and anxiety in CD1 mice by reducing the serum levels of IL-12, TNF-α, IL-1β, and TNF-α in the brain [377]. This evidence concerns the gene IL1B and major depressive disorder.