Ginsenoside Rb1 alleviates HF by targeting the DUSP-1-TMBIM6-VDAC1 signaling axis, coordinating MQC regulation, inhibiting NLRP3 inflammasome-mediated inflammation and pyroptosis, modulating gut microbiota composition, and establishing a protective network, ultimately improving myocardial injury and cardiac function in HF mice [100]. Here, TMBIM6 is linked to hydrops fetalis.