SMC2 and cancer: Of these, key cancer-associated genes shown to be upregulated by the SySa fusion(Jerby-Arnon et al, 2021) were downregulated by TAK-981 treatment, including CDX2, HOXA10, SUZ12, TYMS, AURKB, (Fig. 4A) and HOXC10 and SMC2 (Fig. 4B).