This aberrant interplay between the BAF and PRC complexes results in the upregulation of several oncogenic pathways, including the Wnt/β-catenin (Barham et al, 2013; Ng et al, 2005), FGFR (DeSalvo et al, 2021), and NOTCH (Rota et al, 2012) pathways, while downregulating tumor suppressors such as EGR1 (Ciarapica et al, 2011; Su et al, 2010) and copy number variations of CDKN2A (CDKN2A) Gene Deletion Is a Frequent Genetic Event in Synovial Sarcomas) to name a few. This evidence concerns the gene BANF1 and synovial sarcoma.