STING GOF V154M mouse models develop type I IFN-independent autoinflammatory manifestations, notably lung disease (Motwani et al, 2019; Gao et al, 2022), and also a high decrease of T cell counts in a context of severe combined immunodeficiency (SCID) (Bouis et al, 2019; Motwani et al, 2019), reminiscent of T cell lymphopenia cases among SAVI patients. This evidence concerns the gene STING1 and lung disorder.