STING1 and vascular disorder: Heterozygous gain-of-function (GOF) mutations in STING-coding gene STING1 lead to constitutive activation of the protein and have been described in patients with an autoinflammatory disease designated STING-associated vasculopathy with onset in Infancy (SAVI) (Liu et al, 2014; Jeremiah et al, 2014), classified as a type I interferonopathy, with increased ISGs expression (Crow and Stetson, 2021).