SP3 and idiopathic pulmonary fibrosis: EVs transfer miR-let-7 into MLE-12 cells to inhibit the expression of Sp3, weaken the recruitment of Sp3 to HDAC2, relieve the deacetylation restriction of HDAC2 to Nrf2, and enhance Nrf2 pathway activation, which reduces iron death signaling in the cells and delays the pathological process of oxidative damage and apoptosis of lung epithelial cells in an IPF model151.