In this study, we also find that DKK1 is upregulated in and in NB tumors, and demonstrate that TP-0903 remarkably reduces gene expression and protein level of DKK1 in NB cells, attributing to upregulation of cellular ROS and miR-335-3p and potential binding of TP-0903 to DKK1. Here, DKK1 is linked to neuroblastoma.