ACHE and Parkinsonism: reported the importance of the 2‐thiazoline moiety present at the N‐1 site of isatin, along with the free C‐2 and C‐3 carbonyls, in inhibiting the enzyme acetylcholinesterase (AChE), which is associated with diseases such as Parkinson's, Alzheimer's, and bulbar palsy in humans (Figure 4) [93].