Irrespective of malaria or diabetes status, insulin resistance associated with glucose (B = 0.603, Wald = 10.52, Exp (B) = 1.83, CI: 1.27–2.63; P = 0.001) and insulin (B = 1.145, Wald = 18.61, Exp (B) = 3.14, CI: 1.87–5.23; P < 0.001) levels in our context with the model explaining 67.7% (Cox & Snell R2 = 0.677) to 91% (Nagelkerke R2 = 0.91) of the observed variation. The gene discussed is INS; the disease is diabetes mellitus.