The results showed that, during PRV (MOI = 0.4) infection, compared to the empty vector group, all METTL3 groups (METTL3, METTL3-S43A, METTL3-S50A, and METTL3-S525A) significantly enhanced the mRNA transcription levels of IL-1β (Fig 6C), IL-8 (Fig 6D), IL-6 (Fig 6E) and TNF-α (Fig 6F). The gene discussed is IL1B; the disease is infection.