TSHR and Graves disease: Graves’ disease is an autoimmune condition with multiple hypermetabolic symptoms dueto the interaction of TRAb antibodies with the TSH receptor, leading to increasedsecretion of thyroid hormones (7).In children, Graves’ disease is the most common cause of hyperthyroidism; it is rarebefore the age of 3 years, and its incidence increases progressively, peaking byadolescence (8).