The reassurance of a negative NGAL in this clinical context supports the nonintrinsic AKI component and can guide therapeutic choice.26, –28 Interestingly, the Thrs for uncorrected uNGAL in the cirrhosis population tend to be higher at 220 ng/ml, which was highlighted in a recent meta-analysis.14 Similarly, in patients with acute heart failure and AKI, the development of AKI during escalated diuretic therapy can sometimes prevent effective decongestion because of concerns of superimposed ATN. The gene discussed is LCN2; the disease is acute kidney injury.