NE/LY ratio, a potential biomarker for systemic inflammatory response related to periodontitis,27 some dyslipidemia indicators (decreased HDL-C, increased Trig, LDL-C, CHOL, Trig/HDL ratio due to periodontitis),28 salivary and serum IL-1β and serum MMP-8 levels, which increase with the severity of periodontitis,29 may constitute biomarkers/attributes that can be included in the classification of periodontal status and grading of periodontitis. The gene discussed is IL1B; the disease is periodontitis.