This study aimed to evaluate CA in determining periodontal status and grade in periodontitis patients by adding sociodemographic, anthropometric, medical, and dental anamnesis components, biochemical attributes (whole blood parameters, lipid profiles and salivary and serum IL-1β and MMP-8), and features in the current classification.7 The chosen AI models obtained a high degree of CA in their classification of periodontal status and grading of periodontitis patients. The gene discussed is MMP8; the disease is periodontitis.