TARDBP and amyotrophic lateral sclerosis: Approximately 10% of ALS cases are inherited, with known genetic mutations, including those in Cu/Zn superoxide dismutase (SOD1) [1, 42], TAR DNA-binding protein 43 kDa (TARDBP) encoding TDP-43 [2, 29, 44], fused in sarcoma (FUS) [34, 48], and the hexanucleotide repeat expansion in the C9orf72 gene [16, 41].