Indeed, aside from Lewy bodies, other protein aggregates, especially amyloid-β and tau, which both shape the so-called Alzheimer’s disease (AD)-related co-pathology, may accumulate in the brain of PD patients, with an estimated rate of 65% and 50%, respectively[11, 13], aggravating the α-syn-related neurodegeneration [14] and accelerating the cognitive deterioration [11, 15]. Here, MAPT is linked to Parkinson disease.