MAPT and tauopathy: In particular, we noticed that the accuracy of tauopathy markers in identifying wMC patients was milder for p-tau alone (AUC = 0.68) and higher for the p-tau/Aβ42 ratio (AUC = 0.75) and p-tau/t-tau ratio (AUC = 0.78), the latter being the best predictor for the development of MC in DN patients in the first 5 years (2.6 higher risk in patients above the cut-off value of 0.148).