TP53 and B-cell chronic lymphocytic leukemia: Up to now, eight reported patients exhibited features of histologic transformation with DLBCL-like morphology with CLL-like and non-GCB (Hans) phenotype, were frequently IGHV mutated (5 tested), exhibited trisomy 12 (6/8), TP53 mutation/17p deletion (5/8), and no MYC rearrangement, whereas none showed latent EBV infection by EBER in situ hybridization.