Previous studies have reported heterogeneity in gingival fibroblasts in periodontal tissues, with four subsets significantly altered in periodontitis: Fib 1.1 (CXCL1, CXCL2, CXCL13); Fib 1.2 (APCDD1, IGFBP2, MRPS6); Fib 1.3 (APOD, GSN, CFD); and Fib 1.4 (TIMP3, ASPN, COL11A1). This evidence concerns the gene IGFBP2 and periodontitis.