More convincingly, we found that when TRIM47 and FBP1 overexpression plasmids were co‐transfected, the overexpression of FBP1 rescued the effects of TRIM47 in OS cells (Figure S1), which further supported that FBP1 functions as a crucial mediator of TRIM47 to promote osteosarcoma cell proliferation and invasion by regulating the Wnt/β‐catenin pathway. This evidence concerns the gene TRIM47 and osteosarcoma.