Considering the crucial role of PRMT1 in acute myeloid leukemia (AML) with various gene mutations—including RBM15-MKL1, FLT3-ITD, MLL-EEN, and AML1-ETO fusions—as well as mutations in splicing factor (Fong et al., 2019), PRMT1-mediated metabolic reprogramming may be significant for the previously mentioned AML. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.