The importance of PRMT1 in leukemia has been shown in FLT3-ITD, AML1-ETO, and MLL-EEN-associated acute myeloid leukemia and lymphoid leukemia (Lin et al., 1996; Cheung et al., 2007; Shia et al., 2012; Zou et al., 2012; He et al., 2019). Here, KMT2A is linked to acute myeloid leukemia.