For example, the NeoTCR signature learned across metastatic tumour types identified high expression of the chemokines CXCL13 and CXCR6, effector genes like GZM-A/B/K, and PRF1, and inhibitory markers like TIGIT, PD1, and LAG3, as well as downregulation of stemness markers including IL7R and KLF2 [44]. Here, CXCL13 is linked to neoplasm.