It is curious to us that in the face of the long and well-known neuroinflammatory power of IL-1β in the genesis of both Aβ plaques and neurofibrillary tangles—especially alongside the fact that IL-1β also drives the synthesis and phosphorylation of a-synuclein, which is necessary for formation of the Lewy bodies, the bellwether of Parkinson’s disease—it remains underemphasized [19]. This evidence concerns the gene IL1B and Parkinson disease.