Both mRNA (Figure 2A) and protein levels (Figure 2B,C) of TLR-2, MyD88, NFκB, COX-1, and COX-2 (Figure 2A) were significantly higher in AD 4,4 than in either AD 3,3 or AMC (Figure 2A,B). Here, NFKB1 is linked to Alzheimer disease.