Our identification and quantification of the expression levels of both mRNAs and proteins of three cathepsins, reported [21,22,23,24] to be involved in lysosomal autophagy, as measurements of the both AD 3,3 and AMC3,3 carriers had higher mRNA and protein levels than did AD 4,4 patients (Figure 3A–C), further evidence of the dramatic downregulation of lysosomal autophagy as a result of inheritance of the Alzheimer’s gene (p = 0.0002 for cathepsin B and p = 0.02 for cathepsin L, respectively). Here, CTSS is linked to Alzheimer disease.