APOE and Alzheimer disease: Further, the inheritance of APOEε4 alleles in 50–65 percent of all these cases [2] has the added burden of a diminution in lysosomal autophagy, which, together with a myriad of other untoward features of such APOE4 inheritance, allows for the hypothesis that, in collision, these two driving factors—inheritance of the Alzheimer’s gene, together with IL-1β-engendered neuroinflammation—may be said to account for all or virtually all cases of AD.