What is more, silencing B7-H3 expression has been found to enhance the sensitivity of cancer cells to mTOR inhibitors and paclitaxel by disrupting the JAK2/STAT3 signaling pathway [140,142], while B7-H3-induced activation of the Raf/MEK/ERK signaling has been implicated in promoting lung metastasis [143]. This evidence concerns the gene MAP2K7 and cancer.