Furthermore, anti-B7-H3 monoclonal antibody (mAb) treatment has been shown to promote tumor growth in parental squamous cell carcinoma SCCVII cell line models (p = 0.0005), while adenoviral transfer of B7-H3 resulted in significant tumor size reduction in mouse models of colon cancer [18,19]. Here, CD276 is linked to malignant colon neoplasm.