In a study analyzing B7-H3 expression in a cohort of 408 HNSCC patients, tumors exhibited pronounced staining for B7-H3, and its overexpression was correlated with improved survival outcomes in HPV-negative HNSCC suggesting antitumoral activity of B7-H3 in this subgroup of patients [173]. Here, CD276 is linked to head and neck squamous cell carcinoma.