In the immune context, high levels of B7-H3 were associated with reduced infiltration of tumor-infiltrating lymphocytes and an increase in tumor fibrosis, characteristics that typify the armored-cold phenotype of melanoma—an expression profile associated with low immune checkpoints expression and arising from this resistance to conventional anti-PD-1/PD-L1 agents [75]. This evidence concerns the gene CD276 and neoplasm.