B7-H3 has been reported to be widely expressed in several brain tumors such as glioblastoma (GBM), diffuse intrinsic pontine glioma (DIPG), neuroblastoma, medulloblastoma, atypical teratoid/rhabdoid tumor, craniopharyngioma, and brain metastases [60,61,62,67,82,83,84,85,86]. This evidence concerns the gene CD276 and brain neoplasm.