CD276 and neoplasm: Saeednejad Zanjani et al. did not identify a correlation between membranous B7-H3 expression and clinicopathological parameters; however, cytoplasmic B7-H3 expression was associated with several aggressive features, including lymph node and Gerota's fascia invasion, histological tumor necrosis, tumor size, and tumor grade—showing the highest expression levels in grade IV tumors [160].