Inamura and colleagues noted that elevated CD276 expression, whether in tumor cells or vasculature, was associated with adverse prognostic outcomes primarily in the context of tumors exhibiting high FOXP3+ cell densities, suggesting that B7-H3 may exert its protumor and immunosuppressive effects in RCC predominantly via FOXP3+ regulatory T cells [15]. Here, CD276 is linked to renal cell carcinoma.