Nine shared biomarkers, namely, ACTB, C5, FERMT3, GP1BA, HSP90B1, ITGB3, MASP1, PDIA3 and SERPINA3, were common between the asymptomatic and symptomatic advanced HD stages, and the PLXDC2 protein was shared between the early and symptomatic advanced HD stages (Figure 5A). The gene discussed is SERPINA3; the disease is Huntington disease.