To test the role of myeloid cell intrinsic Jak2–Stat3 signaling inducing obesity-associated insulin resistance, we generated control (Mx1-Cre/Jak2+/+) mice and mice with the hematopoietic cell ablation of Jak2 (Mx1-Cre/Jak2−/−). This evidence concerns the gene STAT3 and obesity due to melanocortin 4 receptor deficiency.