A previous report showed that IA treatment in BC cell lines decreased HKII expression but did not affect the expression of other glycolytic enzymes such as ALDOA and LDH, suggesting that the reduction in HKII expression would mainly affect their participation in the inhibition of apoptosis due to the likely direct binding of IA with HKII observed in the molecular docking analysis [10]. Here, HK1 is linked to breast cancer.