TGFB1 and Cirrhosis: Although the MASH mouse model used in the present studies does not progress to hepatocellular carcinoma (HCC), it is noteworthy that the activation of TGF-β and Hh signaling have been correlated with progression of MASH to HCC [49], and inhibition by Oxy210 may also have beneficial effects on HCC development, which we aim to study in the future using mouse models of MASH that do progress to cirrhosis and HCC [50].