To investigate the role of CD45 and CD148 in the onset and progression of arthritis, we used the STIA model in CD45KO (CD45 knockout, Ptprc-/-), CD148KO (CD148 knockout, Ptprj-/-), and DKO (double knockout, Ptprc-/-Ptprj-/-) mice. This evidence concerns the gene PTPRJ and Arthritis.