PbA-infected control mice developed CM symptoms from day 6 p.i., and all WT mice succumbed to severe illness by day 7, whereas Nr2f6−/− mice developed a moderate score not reaching the cut-off until day 10 p.i. (Figure 1B) Regarding the parasitemia, infected Nr2f6-knock-out mice showed a trend to an attenuated phenotype until day 7, but increased dramatically until day 11 p.i., where mice had to be euthanized due to the development of hyperparasitemia (up to 30% parasitemia) (Figure 1C). Here, NR2F6 is linked to parasitic infectious disease.