MAPT and supranuclear palsy, progressive, 1: In the in vitro binding assay study, using a tritium labeled compound, [3H]HY-2-15, revealed that HY-2-15 has high binding affinities for α-syn aggregations in MSA and PD postmortem brain tissues as well as for misfolded tau proteins in AD, PSP, and CBD brain tissue homogenates.