Interestingly, Hu et al. [164] stably down-regulated PSAP expression in metastatic LNCaP by RNA interference techniques and found that intracellular ceramide levels, CTSD and β1A-integrin expression were decreased, and attenuation of “inside-out” integrin-signaling pathway suggested the involvement of PSAP in PCa invasion. Here, PSAP is linked to posterior cortical atrophy.