Activation of STAT3/NF‐κB mediates inflammation and insulin resistance in adipocytokine‐induced hepatocyte injury.[45] β2‐AR/FOXO1/p‐NF‐κB pathway is activated during restraint stress in pregnant mice.[46] Activation of Cep55/NF‐κB/PI3K/Akt/FOXO1/TNF‐α pathway mediates furosine‐induced toxic effect on Sertoli cells.[47] NF‐κB/SOD2 pathway is involved in the anti‐OS protection in the freeze‐tolerant wood frog. The gene discussed is FOXO1; the disease is Insulin resistance.