It has been reported that inhibition of this pathway aggravated neuron apoptosis, reduced SOD enzyme activity and increased malondialdehyde concentration after cerebral ischemia in rats.[33] In addition, SIRT1/3 can induce deacetylation of PGC‐1α, upregulating NRF1 and NRF2 to participate in mitochondrial biosynthesis and consequently, protecting cells.[34] In this study, HIGD1A‐depletion‐induced downregulation of SIRT1/PGC1α pathway may also be part of the mechanism underlying OS‐induced cell damage. Here, PPARGC1A is linked to brain ischemia.