A recent study underscored the crucial role of hippocampal neuronal Igfbp2 in cognitive development during early life,[30] and Igfbp2 was found to significantly reduce neuronal loss and improve functional recovery in a mouse model of spinal cord injury.[51] Furthermore, Igfbp2 has been shown to have potential therapeutic benefits for Marfan syndrome and posttraumatic stress disorder by enhancing synaptic plasticity.[37, 38] Intriguingly, we also observed synaptic plasticity damage in anesthesia‐treated mice, as evidenced by decreased spine density in the PVT. Here, IGFBP2 is linked to post-traumatic stress disorder.