Tumor cell heterogeneity is regulated by epigenetic mechanisms, including m6A modifications.[37] Dysregulation of m6A writer METTL3,[38] readers YTHDF1/2[39, 40] and IGF2BP1,[41] and the eraser ALKBH5,[42] is implicated in maintaining LCSC stemness. This evidence concerns the gene YTHDF1 and neoplasm.