TCGA data indicated that elevated METTL3 expression in HCC tissues compared with normal liver tissues (Figure S5A, Supporting Information), and high METTL3 expression was associated with poor prognosis (Figure S5B, Supporting Information) and positively correlated with expression of stemness markers including CD133 (Figure S5C–H, Supporting Information). The gene discussed is PROM1; the disease is hepatocellular carcinoma.