ASS1 dysregulation has been implicated in various tumors and plays a crucial role in HCC progression.[25] Our comprehensive multi‐omics analysis with our center cohort and public databases demonstrated a significant downregulation of ASS1 expression in HCC (Figure 6A,B; Figure S6A–G, Supporting Information), and ASS1 expression was associated with favorable prognosis (Figure 6C) and negatively correlated with expression of stemness markers (Figure 6D; Figure S6H–M, Supporting Information). The gene discussed is ASS1; the disease is hepatocellular carcinoma.