Unexpectedly, IGF2BP3 expression was unaltered in HCC cell spheres compared with adherent cells, whereas METTL3, the key methyltransferase of m6A writer complex, was upregulated in both HuH‐7 and HepG2 cell spheres (Figure 4E–G). This evidence concerns the gene METTL3 and hepatocellular carcinoma.