To experimentally confirm the glucose metabolic modulation of HSP90AA1 in PI3K‐AKT signaling pathway, we used 2‐DG and metformin to inhibit glycolysis and oxidative phosphorylation of SLE‐CD4+ T cells, respectively, and then detected the expression change of HSP90AA1. The gene discussed is CD4; the disease is systemic lupus erythematosus.