Quantitative qRT‐PCR measurement showed significantly increased in Ldha expression in MRL/lpr group compared to normal controls (1.74 ± 0.22 vs. 0.99 ± 0.24, p < 0.05), which reduced distinctively in lupus mice administrated with TVI of hUC‐MSCs (1.06 ± 0.18, p < 0.05). Here, LDHA is linked to systemic lupus erythematosus.