ERVFRD-1 and cancer: In humans, HERVs are normally silenced and are considered as “junk DNA.” However, certain specific subsets of HERVs like syncytin‐1, syncytin‐2, and HERV‐K are known to have physiological immunosuppression during placental development and for the immune protection of the fetus.[26, 27, 41] Thus, further research is needed on how this pathological elevation of glycosylated K‐TM subunits occurs in cancer patients.