In this study, we applied AML and PDAC as representatives of hematologic malignancies and solid tumors, respectively, to systematically evaluate the potential role of K‐TM as a representative sample among HERVs accounting for 8% of the human genome in CD8+ T cell dysfunction‐mediated tumor immune evasion, and discovered that the K‐TM subunits were potent driver for immune evasion in AML and PDAC. This evidence concerns the gene CD8A and acute myeloid leukemia.