CD8A and neoplasm: In this study, we applied AML and PDAC as representatives of hematologic malignancies and solid tumors, respectively, to systematically evaluate the potential role of K‐TM as a representative sample among HERVs accounting for 8% of the human genome in CD8+ T cell dysfunction‐mediated tumor immune evasion, and discovered that the K‐TM subunits were potent driver for immune evasion in AML and PDAC.