ROC curve analysis demonstrated that CRP had a relatively strong predictive value for post-NEC intestinal stenosis with an AUC of 0.789, (95% CI: 0.707–0.871), sensitivity of 77.78% (95% CI: 63.9%–87.7%), specificity of 69.81% (95% CI: 59.1%–78.7%), Youden index of 0.476, and a cut-off value of 56.28 mg/L (P < 0.05). This evidence concerns the gene CRP and necrotizing enterocolitis.