In hierarchical multivariate logistic regression, the covariates associated with DPN were age, diabetes duration, HbA1c, type of health care insurance, insulin therapeutic regimen, number of yearly clinical visits, low exercise practice rates, hypertension, dyslipidemia, heart rate, statin use, uric acid levels, lower health‐related quality of life, presence of diabetic retinopathy, and amputations. The gene discussed is INS; the disease is metabolic syndrome.