Consistent with the PDX cell line, the PDX tumor not only exhibited similar expression levels for TP53, PTEN, and RB1 genes when compared with the PDX donor tumor tissue but also increased expression of genes such as E2F family, BCL2L1, KRAS, MYC, CCND1, and TERT genes as well as decreased expression of genes such as PDE4D, LRP1B, NCOR1, and CREBBP genes, which favors the tumorigenic process (Figure S4). Here, PDE4D is linked to neoplasm.