KMT2D and bladder transitional cell carcinoma: However, in the PDX tumor and PDX257S cell line, new SNP and/or insertion/deletion mutations were detected in 25 other genes (Figure S3), including TP53, KMT2D, ARID1A, and KDM6A genes, which were previously found with high mutational incidence (≥ 25%) among urothelial bladder carcinoma and/or MIBC tissue samples [21, 22].