In line with this, most of the genera found to be enriched in Gucy2cS839I/S839I mice are also enriched in IBD patients and include members of the genus Paraprevotella [177,178], Desulfovibrio (enriched in the colonic mucosa and faeces of IBD patients) [179] and Mucispirillum schaedleri that induces Crohn’s disease (CD)-like colitis in Nod2−/− Cybb−/− mice [180]. This evidence concerns the gene CYBB and irritable bowel syndrome.