EZH2 and diffuse large B-cell lymphoma: Indeed, OCI‐LY19, derived from germinal center B‐cell‐like (GCB) DLBCL, displays distinct genetic alterations (BCL2, EZH2, CREBBP), unique epigenetic changes, and activation of BCR signaling and PI3K/AKT/mTOR pathways [81, 82].