This dysregulation elevates pyroptotic rates and lactate dehydrogenase (LDH) release, MALAT1 silencing markedly attenuated HG-induced pyroptosis and reduced NLRP3 inflammasome components such as caspase-1, IL-1β, and IL-18, whilst restoring miR-30c expression—suggesting that KO-MALAT1 suppresses hyperglycemia-induced pyroptosis through miR-30c upregulation and NLRP3 downregulation (96). The gene discussed is MALAT1; the disease is Hyperglycemia.