Beyond their pathogenic roles, circRNA_010383 has been shown to inhibit miR-135a activity by acting as a sponge, thereby up-regulating TRPC1—the target protein of miR-135a—inhibiting ECM FN accumulation, Col-I, and α-SMA, and ameliorating proteinuria, GMCs matrix expansion and kidney fibrosis, inhibiting DN progression, and exerting a protective effect against DN (52). This evidence concerns the gene TRPC1 and liver dysplastic nodule.