SMAD2 and liver dysplastic nodule: Ultimately, targeted inhibition of the circ_0008529/miR-185-5p/SMAD2 and circ_NUP98/miR-151-3p/HMGA2 axis is one of the pathways to inhibit HG-induced cell proliferation, fibrosis, and inflammation, which helps to provide a new perspective for the mechanistic study and treatment of DN (Figure 7, Table 4).