Collectively, circ_AKT3 deregulated the inhibition of E-cadherin by miR-296-3p through the adsorption of miR-296-3p, reducing the rate of HG-induced apoptosis and fibrosis-associated protein expression, whereas circ_LARP1B deregulated the inhibitory effect of miR-578 on TLR4 through the adsorption of miR-578, which in turn activated the TLR4/NLRP3/caspase-1 axis, promoting DN progression. Here, NLRP3 is linked to liver dysplastic nodule.