Additionally, clinically relevant results showed that the expression levels of urinary exosome miRNA-615-3p were positively correlated with serum creatinine (Scr), urea, protein-to-creatinine ratio (PCR), 24-hour urine protein, cystatin C, and TGF-β1, and negatively correlated with eGFR and albumin (129), it shows that miRNA-615-3p in urine exosomes is a key molecule regulating DN. Here, TGFB1 is linked to liver dysplastic nodule.