PTGS2 and colorectal carcinoma: Carriers of the COX-2 A-1195G AG polymorphism have increased risk for CRC and adenoma, and mutation in the adenomatous polyposis coli (APC) gene has been shown to correlate with COX-2 expression in both adenomas and CRCs.10,38,39 More studies are needed to establish the role of race in COX-2 expression in adenoma.